Missegregation of Chromosome 3 and Generation of Monosomy 3 in the Proliferating Uveal Melanoma Cells Under Hyperglycemia
Hyperglycemia can favor chromosome-specific aneuploidies by altering chromosome territories in a cell-type dependent manner. Prevention of hyperglycemia may be a simple therapeutic approach to impede the generation of monosomy 3 in UM.
Authors
- Malte Spielmann (ORCID: https://orcid.org/0000-0002-0583-4683)
- Svenja Rebecca Sonntag
- Salvatore Grisanti (ORCID: https://orcid.org/0000-0003-3700-3590)
- Aysegül Tura
- Nikolas Christian Cornelius von Bubnoff
Institutions
- University Hospital Schleswig-Holstein (DE)
- University of Lübeck (DE)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-12-02
- DOI
- https://doi.org/10.1167/iovs.66.15.10
- Primary Topic
- Ocular Oncology and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00