Photoactive Catalytic EDA Complex-Mediated Synthesis of Difluorinated Polycyclic Indolines
1,4-Diazabicyclo[2.2.2]octane (DABCO) has been demonstrated to function as an effective catalytic electron donor in electron donor-acceptor (EDA) complex-mediated difluoroalkylation reaction. The protocol enables the construction of structurally complex difluorinated polycyclic indoline derivatives with exceptional diastereoselectivity (dr >20:1) via an intramolecular 1,5-hydrogen atom transfer (1,5-HAT) process.
Authors
- Xuebin Zhang (ORCID: https://orcid.org/0000-0003-1731-3524)
- Yingying Xu (ORCID: https://orcid.org/0000-0001-8488-0399)
- Xiangtu Tu
- Haiwei Ye (ORCID: https://orcid.org/0000-0002-6641-0286)
- Xiangyun Zheng (ORCID: https://orcid.org/0000-0003-2042-003X)
Institutions
- Shandong Institute of Food and Drug Inspection (CN)
- Inspection Technologies (United Kingdom) (GB)
- ZheJiang Institute For Food and Drug Control (CN)
- Pharmaceutical Biotechnology (Czechia) (CZ)
- Taizhou Vocational and Technical College (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2025-12-02
- DOI
- https://doi.org/10.1021/acs.joc.5c02186
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00