A fluorescent probe for sulfur dioxide reveals intracellular reductive stress triggered by natural antioxidants
Sulfur dioxide (SO<sub>2</sub>), a pivotal gasotransmitter, is intricately linked to cellular redox homeostasis. Here, we developed the red-emissive DCM-MQE probe for rapid and sensitive detection of intracellular SO<sub>2</sub>. Using this probe, we have demonstrated that natural antioxidants significantly elevate SO<sub>2</sub> levels in both cells and tumor-bearing mice, and confirmed that antioxidants modulate SO<sub>2</sub>-mediated redox homeostasis through induction of reductive stress.
Authors
- Guhuan Liu (ORCID: https://orcid.org/0000-0002-7109-9197)
- Lie Xiang
- Sheng Yang (ORCID: https://orcid.org/0000-0003-0867-6438)
- Sijie Luo
- Huihong Liu
- Lei Shi (ORCID: https://orcid.org/0000-0002-3864-5053)
- Luo Yanyan (ORCID: https://orcid.org/0000-0002-0847-2139)
Institutions
- Hunan Normal University (CN)
- Guangdong Industry Technical College (CN)
- Guangdong Polytechnic Normal University (CN)
- Changsha University of Science and Technology (CN)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-11-24
- DOI
- https://doi.org/10.1039/d5cc05915a
- Citations
- 1
- Primary Topic
- Sulfur Compounds in Biology
- Type
- article
- Field-Weighted Citation Impact
- 1.11