Persistent Head Tremor Improvement in Essential Tremor Patients after Bilateral Ventral Intermediate Nucleus <scp>DBS</scp>

The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions. TABLE S1. STROBE statement-checklist of items for observational studies. Checklist outlining the study's adherence to the STROBE recommendations for observational studies, including item numbers, descriptions, and locations in the manuscript where each item is addressed TABLE S2. Patient characteristics and treatment parameters. This table summarizes the demographic and clinical features of the study cohort (n = 50), along with the optimized DBS stimulation parameters following surgery TABLE S3. Comparison of baseline clinical characteristics and DBS programming parameters between responders and non-responders. Baseline demographic and clinical characteristics, as well as optimized DBS stimulation parameters, compared between patients with and without head tremor improvement following VIM DBS. Values are presented as median (IQR) for continuous non-normally distributed variables and mean (SD) for normally distributed variables. Categorical variables are shown as counts and percentages. Statistical tests included the Wilcoxon rank sum exact test for continuous variables and Fisher's exact test for categorical variables. P < 0.05 are bolded. DBS, deep brain stimulation; VIM, ventral intermediate nucleus of the thalamus; μs, microseconds; mA, milliamperes; Hz, hertz; SD, standard deviation; IQR, interquartile range TABLE S4. Predictors of head tremor improvement following VIM DBS: Exact logistic regression results. Results from exact logistic regression models assessing baseline clinical and stimulation parameters as predictors of head tremor improvement. Odds ratios (ORs) are reported with 95% confidence intervals (CIs), along with P-values and c-statistics for model discrimination Figure S1. Flowchart of patient inclusion for testing. Diagram showing patient screening, inclusion, and exclusion for the study cohort. ET, essential tremor; PD, Parkinson's disease; FTM, Fahn-Tolosa-Marin tremor rating scale; DBS, deep brain stimulation; VIM, ventral-intermediate nucleus of the thalamus. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.