Integrated Multi-Omic Analysis Reveals Causal Relationships and Causal Mechanisms of Peripheral Lymphocyte-Driven Remodeling in the Intrahepatic Immune Microenvironment of Early-Stage MAFLD
We innovatively established that peripheral T lymphocytes exhibit a positive causal relationship with MAFLD development, mediated by Cd5 expression levels. Furthermore, liver-resident Vcam1<sup>high</sup>Kupffer cells may facilitate immune microenvironment remodeling in early MAFLD by recruiting Itgb1⁺Cd5⁺Cd4⁺T cells through the Vcam1-Itgb1 adhesion pathway.
Authors
- Yunpeng Ge (ORCID: https://orcid.org/0000-0002-3981-8972)
- Li Yao (ORCID: https://orcid.org/0000-0002-1120-8435)
- Zhongchao Han (ORCID: https://orcid.org/0000-0002-2687-7682)
- Jinghai Song (ORCID: https://orcid.org/0000-0003-1798-3229)
- Zhengrui Li (ORCID: https://orcid.org/0000-0003-4923-0088)
- Wen Tan (ORCID: https://orcid.org/0000-0002-7231-7838)
- Shiqi Guo (ORCID: https://orcid.org/0000-0002-9287-4041)
- Haowei Shi (ORCID: https://orcid.org/0009-0004-7608-4877)
- Yangyang Zheng (ORCID: https://orcid.org/0000-0003-0976-7024)
- Xing Cheng (ORCID: https://orcid.org/0000-0002-4059-1939)
- Zhichao Li
Institutions
- Shanghai Jiao Tong University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking University (CN)
- National Cancer Center (US)
- Shanghai Ninth People's Hospital (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2025-12-01
- DOI
- https://doi.org/10.2147/jir.s546860
- Primary Topic
- T-cell and B-cell Immunology
- Type
- article
- Field-Weighted Citation Impact
- 0.00