Peripheral blood tRNA-derived fragments as novel noninvasive biomarkers for diagnosis and prognostic stratification in multiple myeloma
Our findings reveal a distinct imbalance in tsRNA expression in MM, indicating that specific tsRNA fragments contribute to disease progression and renal injury through multifaceted signaling networks, thereby providing novel molecular insights for early diagnosis and risk stratification.
Authors
- Rong Liu (ORCID: https://orcid.org/0000-0003-2937-4658)
- Yanzhao Huang
- Mengying Zeng (ORCID: https://orcid.org/0009-0000-0450-0932)
- Xu Han (ORCID: https://orcid.org/0000-0001-7915-8609)
- Bin Yi (ORCID: https://orcid.org/0000-0002-6247-8320)
- Ming Lei
- Yan Gao (ORCID: https://orcid.org/0000-0001-8147-8425)
- Kaiyun Guo
Institutions
- Central South University (CN)
- The First People's Hospital of Changde (CN)
- University of South China (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-12-03
- DOI
- https://doi.org/10.3389/fimmu.2025.1650510
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00