Irisin-induced cardiac fibroblast proliferation is dependent on glucose concentration and is inhibited by WZB117.
Irisin accelerates cardiac fibroblast proliferation and glucose uptake; however, this effect is dependent on glucose concentration and GLUT1 activity. GLUT1, 3 and 4 protein expression was identified on human cardiac fibroblasts.
Authors
- Jacek Drobnik (ORCID: https://orcid.org/0000-0002-7329-7613)
- Małgorzata Gałdyszyńska (ORCID: https://orcid.org/0000-0002-0232-5795)
- Marlena Juszczak (ORCID: https://orcid.org/0000-0002-0379-8236)
- Jacek Szymański (ORCID: https://orcid.org/0000-0003-0428-7654)
- Marta Drobnik
- Aleksander Kucner
Institutions
- Medical University of Lodz (PL)
Publication Details
- Journal
- Molecular Biology Reports
- Published
- 2025-12-03
- DOI
- https://doi.org/10.1007/s11033-025-11307-3
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Uniwersytet Łódzki