Individualized prediction of clinical progression to dementia using plasma biomarkers in non-demented elderly
Our prediction models have utility for clinical practice to calculate progression probabilities for development of dementia in individual patients living with MCI over a 1-, 3- and 5-year time period.
Authors
- Calvin Trieu (ORCID: https://orcid.org/0000-0001-6266-2198)
- Argonde C. van Harten (ORCID: https://orcid.org/0000-0002-1477-8724)
- James D. Doecke (ORCID: https://orcid.org/0000-0003-2863-0293)
- David H. Wilson (ORCID: https://orcid.org/0000-0001-8322-0380)
- Mariam Gouda (ORCID: https://orcid.org/0009-0003-4187-3131)
- Wiesje M. van der Flier (ORCID: https://orcid.org/0000-0001-8766-6224)
- Ingrid S. van Maurik (ORCID: https://orcid.org/0000-0001-6919-8340)
- Colin Louis Masters (ORCID: https://orcid.org/0000-0003-3072-7940)
- Arenda Mank
- Inge M.W. Verberk (ORCID: https://orcid.org/0000-0003-0341-7445)
- Isabelle Pellegrin (ORCID: https://orcid.org/0000-0001-7731-6474)
- Madison I. J. Honey (ORCID: https://orcid.org/0000-0002-9422-8764)
- Charlotte Elisabeth Teunissen (ORCID: https://orcid.org/0000-0002-4061-0837)
- Geneviève Chêne (ORCID: https://orcid.org/0000-0002-8368-6460)
- Christopher James Fowler (ORCID: https://orcid.org/0000-0003-1397-0359)
- Vincent Bouteloup (ORCID: https://orcid.org/0009-0008-9956-862X)
- Yolande A.L. Pijnenburg (ORCID: https://orcid.org/0000-0003-2464-1905)
- Carole Dufouil
- Mardou van Leeuwenstijn
Institutions
- Université de Bordeaux (FR)
- Inserm (FR)
- The University of Melbourne (AU)
- Florey Institute of Neuroscience and Mental Health (AU)
- Centre Hospitalier Universitaire de Bordeaux (FR)
- Northwest Hospital (US)
- Bordeaux Population Health (FR)
- Amsterdam Neuroscience (NL)
- Quanterix (United States) (US)
- Australian e-Health Research Centre (AU)
- CSIRO Health and Biosecurity (AU)
- Amsterdam University Medical Centers (NL)
- Vrije Universiteit Amsterdam (NL)
Publication Details
- Journal
- Alzheimer s Research & Therapy
- Published
- 2025-12-03
- DOI
- https://doi.org/10.1186/s13195-025-01925-1
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministère de l'Enseignement supérieur, de la Recherche et de l'Innovation
- Institut National de la Santé et de la Recherche Médicale
- Université de Bordeaux
- Alzheimer Nederland