Prevalence and Clinical Implications of Excess Adiposity in Group 1 Pulmonary Hypertension
Excess adiposity is common in group 1 PH, occurring in 4 out of 5 patients by the more sensitive waist/height ratio, in contrast to only 2 out of 5 patients having obesity by traditional BMI criteria. Excess adiposity is associated with higher biventricular filling pressures, cardiac output demand, worse functional status and reduced survival. These data support trials of adipose-reducing therapies in patients with group 1 PH and excess adiposity.
Authors
- J. Emanuel Finet (ORCID: https://orcid.org/0000-0002-0156-6757)
- Paul M. Hassoun (ORCID: https://orcid.org/0000-0003-0601-4975)
- SERPIL CEM ERZURUM (ORCID: https://orcid.org/0000-0001-5202-9065)
- Barry A. Borlaug (ORCID: https://orcid.org/0000-0001-9375-0596)
- Yogesh N.V. Reddy (ORCID: https://orcid.org/0000-0001-5322-0902)
- Stephen C. Mathai (ORCID: https://orcid.org/0000-0003-3188-7209)
- W.H. Wilson Tang (ORCID: https://orcid.org/0000-0002-8335-735X)
- Christine Jellis (ORCID: https://orcid.org/0000-0002-8610-0533)
- Evelyn M. Horn (ORCID: https://orcid.org/0000-0002-5751-9415)
- Anna R. Hemnes (ORCID: https://orcid.org/0000-0002-2755-5845)
- Jane A. Leopold (ORCID: https://orcid.org/0000-0003-0598-8882)
- Franz Rischard (ORCID: https://orcid.org/0000-0002-6861-8304)
- Nicholas S. Hill (ORCID: https://orcid.org/0000-0002-8242-8339)
- Robert P. Frantz (ORCID: https://orcid.org/0000-0003-4128-3978)
- Erika B. Rosenzweig (ORCID: https://orcid.org/0000-0003-4849-214X)
- Gerald J. Beck (ORCID: https://orcid.org/0000-0002-8876-5045)
Institutions
- Brigham and Women's Hospital (US)
- Tufts Medical Center (US)
- Cleveland Clinic (US)
- Mayo Clinic (US)
- Johns Hopkins University (US)
- Cornell University (US)
- Columbia University Irving Medical Center (US)
- Johns Hopkins Medicine (US)
- Cleveland Clinic Lerner College of Medicine (US)
- Pulmonary and Allergy Associates (US)
- Mayo Clinic in Arizona (US)
- Mayo Clinic in Florida (US)
- Columbia University (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Circulation Heart Failure
- Published
- 2025-12-03
- DOI
- https://doi.org/10.1161/circheartfailure.125.013591
- Primary Topic
- Pulmonary Hypertension Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00