XLOC_010588 Promotes Mitophagy Via BAG2-Mediated PINK1 Stabilization in HPH
Our study reveals a novel mechanism in which XLOC_010588 promotes mitophagy via BAG2-dependent suppression of PINK1 ubiquitination, contributing to pulmonary artery smooth muscle cell proliferation and HPH development. These findings highlight the potential of targeting the XLOC_010588/BAG2/PINK1 axis for HPH treatment.
Authors
- Jiling Wang
- Binbin Zhang (ORCID: https://orcid.org/0000-0003-2000-6402)
- Daxiong Zeng
- Pulin Li (ORCID: https://orcid.org/0000-0002-8525-4936)
- Rui Han (ORCID: https://orcid.org/0000-0002-7729-9165)
- Wenlong Wu (ORCID: https://orcid.org/0000-0002-7630-6255)
- Wenhao Li (ORCID: https://orcid.org/0009-0001-5031-8717)
- Ran Wang (ORCID: https://orcid.org/0000-0002-3016-1011)
- Can Wang (ORCID: https://orcid.org/0009-0006-9851-2902)
Institutions
- Anhui Medical University (CN)
- Soochow University (CN)
- Second Affiliated Hospital of Soochow University (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
- Second Affiliated Hospital of Anhui Medical University (CN)
- First Affiliated Hospital of Soochow University (CN)
- Third People's Hospital of Hefei (CN)
- Hefei Infectious Disease Hospital (CN)
Publication Details
- Journal
- Hypertension
- Published
- 2025-12-03
- DOI
- https://doi.org/10.1161/hypertensionaha.125.25742
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 0.00