effects of chronic use of diclofenac sodium and meloxicam in liver and kidney of sheep model: Histopathological evaluation.....

Non-steroidal anti-inflammatory medicines (NSAIs) are the most often prescribed medications nowadays. The fact that conventional NSAIs have been shown to produce hepatic and renal damage has limited the intake of these medicines for treatment of pain and inflammatory conditions. Objectives: to study the histopathological changes of liver and kidney induced by chronic use of diclofenac sodium and meloxicam on in sheep model, Material and method: Fifteen mature healthy male sheep were assimilated in the research. Sheep were divided at random into 3 groups: Group 1(5 animals): not administered by any drugs. Group 2 (5 animals): administered diclofenac sodium (1mg/kg/day). Group 3(5 animals): administered meloxicam (0.5 mg/kg/day). Results: The Microscopic examination of kidney and liver specimens from normal group expression normal usual tissue architectural , while histopathological analysis of kidney and liver from diclofenac and meloxicam treated animals show renal and hepatic tissues destruction. These alterations were observed systemically and reflected to be a side effects related with these medications. Conclusion: possibilities of amplified hepatic and renal destruction due to a elongated interval use of diclofenac sodium and meloxicam. Although its effective in pain management their damaging effects must be well thought-out during the continual medication.Keywords: diclofenac sodium, meloxicam, sheep, liver, kidney.