Contribution of comorbid pathologies to amyotrophic lateral sclerosis with cognitive or behavioral abnormalities
A high frequency of comorbid pathologies is observed in elderly patients with ALS presenting with cognitive or behavioral abnormalities. There are cases of ALS in which comorbid pathologies such as AD, AGD, and PART may contribute to cognitive or behavioral abnormalities, even in the absence of cortical TDP-43 pathology. Hippocampal sclerosis of ALS may contribute to memory impairment independently of comorbid pathologies.
Authors
- Yuichi Riku (ORCID: https://orcid.org/0000-0002-6493-8976)
- Mari Yoshida (ORCID: https://orcid.org/0000-0002-8520-6184)
- Jun Sone (ORCID: https://orcid.org/0000-0002-9057-7609)
- Masahisa Katsuno (ORCID: https://orcid.org/0000-0001-9453-9311)
- Yasushi Iwasaki (ORCID: https://orcid.org/0000-0002-0059-3104)
- Akio Akagi (ORCID: https://orcid.org/0000-0003-4712-7562)
- Hiroaki Miyahara (ORCID: https://orcid.org/0000-0003-0723-0047)
- Hideyuki Moriyoshi (ORCID: https://orcid.org/0000-0002-2737-9669)
Institutions
- Aichi Medical University (JP)
- Nagoya University (JP)
Publication Details
- Journal
- BMC Neurology
- Published
- 2025-12-03
- DOI
- https://doi.org/10.1186/s12883-025-04556-z
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00