Mechanosensitive Piezo1 Channels Mediate Diaphragm Fibrosis Induced by Prolonged Mechanical Ventilation
Piezo1 upregulation is a key mechanism in ventilator-induced diaphragm fibrosis, potentially mediated through the Akt/Nr4a1 signalling pathway. Targeted inhibition of Piezo1 or activation of Nr4a1 presents a promising therapeutic strategy to prevent fibrosis and preserve diaphragm function.
Authors
- Dan Xie (ORCID: https://orcid.org/0000-0001-5388-5541)
- Li Liu (ORCID: https://orcid.org/0000-0002-0680-5139)
- Xuexin Li (ORCID: https://orcid.org/0000-0001-5824-9720)
- Yuru Xiao (ORCID: https://orcid.org/0000-0001-6501-1331)
- Jianguo Feng (ORCID: https://orcid.org/0000-0002-5830-3317)
- Jing Jia (ORCID: https://orcid.org/0000-0001-8415-4223)
- Bowen Sun (ORCID: https://orcid.org/0009-0004-2714-647X)
- Yun Wang (ORCID: https://orcid.org/0000-0002-5640-5010)
- Fei He
- Jie Li (ORCID: https://orcid.org/0000-0003-1136-9842)
Institutions
- Southwest Medical University (CN)
- Affiliated Hospital of Southwest Medical University (CN)
- Affiliated Hospital of North Sichuan Medical College (CN)
Publication Details
- Journal
- Journal of Cachexia Sarcopenia and Muscle
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/jcsm.70136
- Primary Topic
- Erythrocyte Function and Pathophysiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00