Comparison of cefazolin administered as a continuous or intermittent infusion for prophylaxis of surgical site infections in adult patients undergoing cardiac or neurologic surgery
In a propensity-matched cohort of adult cardiac or neurosurgical procedures (<i>n</i> = 1,342), infection was less frequent with continuous infusion (1.8%) versus intermittent cefazolin (2.4%), though the difference was statistically non-significant (-0.6%, 95% CI-2.3 to 1.1; <i>p</i> = 0.57). The 0% infection rate among cardiac cases receiving continuous cefazolin infusion warrants further investigation.
Authors
- Elizabeth Keil (ORCID: https://orcid.org/0000-0001-8115-499X)
- Nicholas Turner (ORCID: https://orcid.org/0000-0003-0650-4894)
- Jessica Seidelman (ORCID: https://orcid.org/0000-0001-7117-513X)
- Richard H. Drew (ORCID: https://orcid.org/0000-0003-0406-0804)
Institutions
- Campbell University (US)
- Duke University (US)
- Swedish Medical Center (US)
- HealthONE (US)
Publication Details
- Journal
- Infection Control and Hospital Epidemiology
- Published
- 2025-12-03
- DOI
- https://doi.org/10.1017/ice.2025.10365
- Primary Topic
- Surgical site infection prevention
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases