Relationship between diabetes mellitus and stomach cancer, the effect of metformin on the course of diseases and prognosis

The article discusses the relationship between diabetes mellitus and stomach cancer, as well as the impact of metformin on the prognosis of patients with these conditions. Most studies suggest that patients with diabetes mellitus have an increased risk of developing stomach cancer. Patients with diabetes mellitus and stomach cancer are more likely to experience complications after gastrectomy, and their prognosis may be worse than that of patients without diabetes mellitus. However, patients with diabetes mellitus and stomach cancer may experience improved glycemic control after gastrectomy. The association between diabetes mellitus and gastric cancer may be due to common risk factors such as hyperglycemia, poor diet, smoking, Helicobacter pylori infection, and the use of certain medications, such as insulin, metformin, statins, aspirin, and proton pump inhibitors. Some studies suggest that the use of metformin may reduce the risk of gastric cancer in patients with type 2 diabetes mellitus. This is supported by numerous in vitro and animal model studies. Metformin can also reduce the risk of Helicobacter pylori infection, which is an important risk factor for stomach cancer. Additionally, metformin has been shown to improve survival rates and reduce the incidence of recurrence in patients with stomach cancer.