An <i>in vitro</i> organ-on-chip model for studying neuron–keratinocyte interactions in sensory response through electrophysiology
This study introduces a human-relevant <i>in vitro</i> model using iPSC-derived sensory neurons and keratinocytes in MEA-integrated microfluidic chips. Neurons expressed nociceptor markers, showed TRPV activity, and formed contacts with keratinocytes. Stimuli evoked electrophysiological responses, highlighting neuron-keratinocyte interactions relevant to pruritus, pain, and skin disorders, supporting therapeutic development.
Authors
- Anthony Martinez
- Damien Lelièvre (ORCID: https://orcid.org/0000-0002-8051-8058)
- Camille Baquerre
- Louise Dubuisson
- Aurélie Batut
- A Guichard (ORCID: https://orcid.org/0000-0002-1034-8815)
- Corinne Grégoire
- Thomas Bessy (ORCID: https://orcid.org/0000-0001-9911-4400)
- Séverine Teluob
- Audrey Azéma
- Laurène Roussel Berlier
- Aurore Berthelin
Institutions
- L'Oréal (France) (FR)
- Mapi Research Trust (FR)
- Alexander Fleming Biomedical Sciences Research Center (GR)
Publication Details
- Journal
- Lab on a Chip
- Published
- 2025-12-03
- DOI
- https://doi.org/10.1039/d5lc00867k
- Citations
- 1
- Primary Topic
- 3D Printing in Biomedical Research
- Type
- article
- Field-Weighted Citation Impact
- 0.67