Use of Rifampicin as a Cytochrome Inducer in Acute Tacrolimus Poisoning
Tacrolimus is an essential immunosuppressive drug in lung transplantation. It is metabolized by cytochrome P450, which can cause interactions with many drugs. We present a case of acute tacrolimus poisoning in a lung transplant patient following administration of nirmaltrevir/ritonavir, as well as treatment with rifampicin, acytochrome inducer, which allowed blood levels of tacrolimus to be reduced to appropriate values.
Authors
- Alicia de Pablo Gafas (ORCID: https://orcid.org/0000-0003-3373-8135)
- Rodrigo Alonso (ORCID: https://orcid.org/0000-0002-7833-5084)
- M. Mar Rodríguez
- Juan Margallo Iribarnegaray (ORCID: https://orcid.org/0000-0001-8805-1600)
- Lucía Ortega Ruiz
- Carlos Andrés Quezada Loaiza
Institutions
- Hospital Universitario 12 De Octubre (ES)
Publication Details
- Journal
- Open Respiratory Archives
- Published
- 2025-12-03
- DOI
- https://doi.org/10.1016/j.opresp.2025.100528
- Primary Topic
- Renal Transplantation Outcomes and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00