Dendrobine promotes bone formation via the canonical Wnt/β-catenin signaling pathway and prevents postmenopausal osteoporosis
In OVX mice, dendrobine attenuated the loss of cancellous bone, as shown in micro-computed tomography analysis. Dendrobine activated the Wnt/β-catenin pathway by suppressing the phosphorylation level of GSK-3β at Tyr216 site while keeping the level of β-catenin sustaining. This study suggests that dendrobine may be an effective treatment for postmenopausal osteoporosis.
Authors
- Haixiong Miao
- Shengfa Li (ORCID: https://orcid.org/0009-0005-6801-7102)
- Jian Chen (ORCID: https://orcid.org/0000-0003-2735-3925)
- Youming Zhang (ORCID: https://orcid.org/0000-0001-5403-4044)
- Ting Wang (ORCID: https://orcid.org/0009-0006-7734-2094)
- Peili Liang
Institutions
- Jinan University (CN)
- Third Affiliated Hospital of Guangzhou Medical University (CN)
- Third People's Hospital of Chengdu (CN)
- Chongqing Three Gorges Central Hospital (CN)
- Chongqing Three Gorges University (CN)
- Chongqing Medical University (CN)
- Guangzhou Medical University (CN)
- Tsinghua University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-12-03
- DOI
- https://doi.org/10.3389/fphar.2025.1616070
- Primary Topic
- Wnt/β-catenin signaling in development and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Science Foundation
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province