Anti-interferon-γ Autoantibodies and Indeterminate QuantiFERONⓇ-TB Gold Plus Assays
Among 852 samples sent for QuantiFERON<sup>®</sup>-TB Gold Plus Assay (QFN) analysis, between 6% and 11% had IFNγ binding activity, but only 1.2% of indeterminate samples had IFNγ blocking activity. No TB negative samples had blocking activity to IFNγ. Indeterminate QFN results may indicate the presence of blocking anti-IFNγ autoantibodies.
Authors
- Stanley J. Naides (ORCID: https://orcid.org/0000-0001-9339-7104)
- Annalie J Harris (ORCID: https://orcid.org/0009-0007-8231-8002)
- Steven M. Holland (ORCID: https://orcid.org/0000-0003-3207-5464)
- Lindsey B. Rosen (ORCID: https://orcid.org/0000-0001-5894-3878)
- Christa S. Zerbe (ORCID: https://orcid.org/0000-0003-4219-0503)
- Charles Walworth
- Serena Lee
Institutions
- National Institutes of Health (US)
- LabCorp (United States) (US)
- Office of Extramural Research (US)
- National Institutes of Health Clinical Center (US)
Publication Details
- Journal
- Open Forum Infectious Diseases
- Published
- 2025-11-26
- DOI
- https://doi.org/10.1093/ofid/ofaf734
- Citations
- 1
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 1.40
Funders
- NHLBI Division of Intramural Research