Huanglian Jiedu Decoction Alleviates Myocardial Ischemia-Reperfusion Injury via AKT-Mediated Regulation of Endoplasmic Reticulum Stress
HLJDD may serve as a potential therapeutic candidate for ischemia-induced cardiomyocyte apoptosis during MIRI. HLJDD exerts its effects by inhibiting the AKT-mediated PERK/eIF2α/CHOP signaling pathway, attenuating ERS and thereby reducing MIRI-induced apoptosis.
Authors
- Jinhai Lin (ORCID: https://orcid.org/0000-0003-0745-0904)
- Wei Wu (ORCID: https://orcid.org/0009-0005-1713-3330)
- Yijun Qiu (ORCID: https://orcid.org/0009-0009-5153-126X)
- Mingyang Gu (ORCID: https://orcid.org/0009-0005-4965-8502)
- Rui Li (ORCID: https://orcid.org/0000-0002-7210-8358)
- Zhihong Liao (ORCID: https://orcid.org/0000-0003-1257-0767)
- Jiongbo Xu
Institutions
- Guangzhou University of Chinese Medicine (CN)
- First Affiliated Hospital of Guangzhou University of Chinese Medicine (CN)
- Guangdong Academy of Medical Sciences (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2025-12-01
- DOI
- https://doi.org/10.2147/jir.s535348
- Citations
- 1
- Primary Topic
- Endoplasmic Reticulum Stress and Disease
- Type
- article
- Field-Weighted Citation Impact
- 1.15