Comparison of Amniotic Membrane Extract and Insulin Eye Drops for the Management of Persistent Epithelial Defects: A Multicenter Retrospective Study
Topical insulin and AMEED are both safe and effective for refractory PEDs, but insulin showed superior epithelial healing and visual recovery. Given its availability, low cost, and favorable safety profile, topical insulin may represent a practical alternative in the management of persistent epithelial defects.
Authors
- Giulia Coco (ORCID: https://orcid.org/0000-0002-2410-6366)
- Matilde Buzzi (ORCID: https://orcid.org/0000-0002-2142-4596)
- Giuseppe Giannaccare (ORCID: https://orcid.org/0000-0003-2617-0289)
- Vincenzo Scorcia (ORCID: https://orcid.org/0000-0001-6826-7957)
- Andrea Taloni (ORCID: https://orcid.org/0000-0002-4367-0747)
- Adriano Carnevali (ORCID: https://orcid.org/0000-0002-9950-6743)
- Livio Vitiello (ORCID: https://orcid.org/0000-0001-7867-3342)
- Rita Mencucci (ORCID: https://orcid.org/0000-0003-1856-6363)
- Andrea Lucisano (ORCID: https://orcid.org/0000-0003-1382-0828)
- Giovanna Carnovale-Scalzo
- Alessandra Mancini (ORCID: https://orcid.org/0000-0001-7719-5772)
- Mario Verdiglione
- Filippo Lixi (ORCID: https://orcid.org/0009-0008-0956-4925)
- Giovanni Romualdi (ORCID: https://orcid.org/0009-0003-6906-5021)
- Benedetta Pintus
- Valerio Calabresi (ORCID: https://orcid.org/0009-0008-4716-7154)
Institutions
- University of Rome Tor Vergata (IT)
- University of Cagliari (IT)
- University of Ferrara (IT)
- Magna Graecia University (IT)
- ASL Roma (IT)
- Gruppo Italiano per lo Studio dei Carcinomi dell’Apparato Digerente (IT)
- Istituto Nazionale di Documentazione Innovazione e Ricerca Educativa (IT)
- Accademia di Belle Arti di Catanzaro (IT)
- University of Florence (IT)
Publication Details
- Journal
- Clinical ophthalmology
- Published
- 2025-12-01
- DOI
- https://doi.org/10.2147/opth.s561775
- Citations
- 1
- Primary Topic
- Corneal Surgery and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.36