Bridging East and West: Real-World Clinicogenomic Landscape of Metastatic NSCLC in Türkiye
In this large, multicenter Turkish real-world cohort, the TGA spectrum broadly mirrors global patterns while revealing local nuances; EGFR mutations were more frequent than expected in SCC, and nationwide NGS adoption is accelerating. Limitations include retrospective design, non-centralized PD-L1 testing, and missing data. Prospective, standardized studies integrating outcomes and resistance mechanisms are warranted to refine regional precision oncology.
Authors
- Öznur Bal (ORCID: https://orcid.org/0000-0002-6901-2646)
- Feyyaz Özdemir (ORCID: https://orcid.org/0000-0001-6980-2800)
- Mehmet Bilici (ORCID: https://orcid.org/0000-0003-1306-2238)
- Kübra Canaslan (ORCID: https://orcid.org/0000-0001-7705-3926)
- Hande Turna (ORCID: https://orcid.org/0000-0003-0558-9371)
- Zuhat Urakçı (ORCID: https://orcid.org/0000-0003-3878-988X)
- Ebru Çiçek (ORCID: https://orcid.org/0000-0002-6808-8905)
- Hayati Arvas (ORCID: https://orcid.org/0000-0003-2215-5567)
- Fahriye Merve Balcıoğlu (ORCID: https://orcid.org/0000-0003-4124-3992)
- Banu Öztürk (ORCID: https://orcid.org/0000-0003-0290-8787)
- Görkem Turhan (ORCID: https://orcid.org/0000-0002-0572-4927)
- Aziz Karaoğlu (ORCID: https://orcid.org/0000-0001-5500-156X)
- Mehmet Çakmak (ORCID: https://orcid.org/0000-0002-5362-6109)
- Emre Eken
Institutions
- Dicle University (TR)
- Karadeniz Technical University (TR)
- Bilkent University (TR)
- Dokuz Eylül University (TR)
- Antalya Eğitim ve Araştırma Hastanesi (TR)
- Istanbul University-Cerrahpaşa (TR)
- Atatürk University (TR)
- Istanbul University (TR)
Publication Details
- Journal
- Genes
- Published
- 2025-12-03
- DOI
- https://doi.org/10.3390/genes16121446
- Primary Topic
- Lung Cancer Treatments and Mutations
- Type
- article
- Field-Weighted Citation Impact
- 0.00