Genomic pathogenic alterations in the SWI/SNF complex compromise the outcomes of immunotherapy in Chinese patients with KRAS-mutant NSCLC by downregulating STING expression
In KRAS-mut NSCLCs with or without STK11/KEAP1 mutations, the GPAs in the DNA-binding genes ARID1A/ARID2 affected the outcomes of immunotherapy, possibly through the downregulation of STING expression.
Authors
- Wenqing Yan (ORCID: https://orcid.org/0000-0002-5405-4026)
- Haiyu Zhou (ORCID: https://orcid.org/0000-0002-3328-6792)
- Weineng Feng (ORCID: https://orcid.org/0000-0001-5453-8605)
- Dongkun Zhang (ORCID: https://orcid.org/0000-0002-0811-4964)
- Shuilian Zhang
- Jie Jiang (ORCID: https://orcid.org/0000-0002-9634-4152)
- Xiaodan Huang (ORCID: https://orcid.org/0000-0001-9264-9891)
- Penghui Zeng
- Yuqing Chen (ORCID: https://orcid.org/0009-0006-6386-1782)
- Zhi Xie (ORCID: https://orcid.org/0000-0002-5589-4836)
- Xue‐Ning Yang (ORCID: https://orcid.org/0000-0002-8346-2117)
- Zhiyi Lv (ORCID: https://orcid.org/0000-0002-1687-4277)
- Xu‐Chao Zhang (ORCID: https://orcid.org/0000-0002-4138-8115)
- Zunfu Ke (ORCID: https://orcid.org/0000-0002-6251-7246)
- Binchao Wang
- Yumin Zhong
- Yu Chen (ORCID: https://orcid.org/0000-0003-1348-8992)
- Li Zhang (ORCID: https://orcid.org/0000-0003-2039-2526)
- Ji Chen (ORCID: https://orcid.org/0000-0001-7026-6312)
- Danxia Lu
- Linlin Zhu
- Lingling Gao (ORCID: https://orcid.org/0000-0002-0159-4344)
- Wenbin Zhou (ORCID: https://orcid.org/0000-0003-1855-0134)
- Hongling Liang (ORCID: https://orcid.org/0000-0001-5474-7888)
- Wei‐Bang Guo
Institutions
- Sun Yat-sen University (CN)
- First People's Hospital of Foshan (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Guangdong Academy of Medical Sciences (CN)
- Guangzhou Medical University Cancer Hospital (CN)
- Guangdong Provincial People's Hospital (CN)
- Southern Medical University (CN)
- South China University of Technology (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- BMC Medicine
- Published
- 2025-12-03
- DOI
- https://doi.org/10.1186/s12916-025-04561-6
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00