Genomic pathogenic alterations in the SWI/SNF complex compromise the outcomes of immunotherapy in Chinese patients with KRAS-mutant NSCLC by downregulating STING expression

In KRAS-mut NSCLCs with or without STK11/KEAP1 mutations, the GPAs in the DNA-binding genes ARID1A/ARID2 affected the outcomes of immunotherapy, possibly through the downregulation of STING expression.

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Publication Details

Journal
BMC Medicine
Published
2025-12-03
DOI
https://doi.org/10.1186/s12916-025-04561-6
Primary Topic
interferon and immune responses
Type
article
Field-Weighted Citation Impact
0.00
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article

Genomic pathogenic alterations in the SWI/SNF complex compromise the outcomes of immunotherapy in Chinese patients with KRAS-mutant NSCLC by downregulating STING expression

Wenqing Yan, Haiyu Zhou, Weineng Feng, Dongkun Zhang et al.
BMC Medicine
interferon and immune responses
article

Genomic pathogenic alterations in the SWI/SNF complex compromise the outcomes of immunotherapy in Chinese patients with KRAS-mutant NSCLC by downregulating STING expression

Wenqing Yan, Haiyu Zhou, Weineng Feng, Dongkun Zhang, Shuilian Zhang, Jie Jiang, Xiaodan Huang, Penghui Zeng, Yuqing Chen, Zhi Xie, Xue‐Ning Yang, Zhiyi Lv, Xu‐Chao Zhang, Zunfu Ke, Binchao Wang, Yumin Zhong, Yu Chen, Li Zhang, Ji Chen, Danxia Lu, Linlin Zhu, Lingling Gao, Wenbin Zhou, Hongling Liang, Wei‐Bang Guo
article en

Abstract

In KRAS-mut NSCLCs with or without STK11/KEAP1 mutations, the GPAs in the DNA-binding genes ARID1A/ARID2 affected the outcomes of immunotherapy, possibly through the downregulation of STING expression.

BMC MedicineVol. 24(1)
Sun Yat-sen University (CN), First People's Hospital of Foshan (CN), The First Affiliated Hospital, Sun Yat-sen University (CN), Guangdong Academy of Medical Sciences (CN), Guangzhou Medical University Cancer Hospital (CN), Guangdong Provincial People's Hospital (CN), Southern Medical University (CN), South China University of Technology (CN), Guangzhou Medical University (CN)
Openalex Percentile: Top 57%
interferon and immune responses
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