Lymphatic mimicry of spiral arteries is impaired by human sFLT1 overexpression in a preeclampsia mouse model
With this study we could show that increased levels of human sFLT1 interfere with early spiral artery (SpA) remodeling processes and could inhibit lymphatic mimicry of SpA. Immune cell infiltration until 14.5 dpc could be decreased by downregulation of the chemotactic chemokine Ccl21.
Authors
- Sylvia Voortmann
- Bernd Walkenfort (ORCID: https://orcid.org/0000-0002-7789-3340)
- Alexandra Gellhaus (ORCID: https://orcid.org/0000-0001-9506-4581)
- Rainer Kimmig (ORCID: https://orcid.org/0000-0003-1118-2199)
- Alina Riedel (ORCID: https://orcid.org/0009-0000-3404-2573)
- Elke Winterhager
- Christopher Mohr (ORCID: https://orcid.org/0000-0003-4237-2251)
- Elisa Marie Elfroth
Institutions
- Essen University Hospital (DE)
Publication Details
- Journal
- Placenta
- Published
- 2025-12-03
- DOI
- https://doi.org/10.1016/j.placenta.2025.12.002
- Primary Topic
- Lymphatic System and Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00