Nodal response to neoadjuvant therapy predicts prognosis of breast cancer patients with clinically positive internal mammary nodes
The dual achievement of IMN cCR and ALN pCR after NAT predicts exceptional outcomes. For patients with persistent IMN involvement after NAT, IMN dose escalation to ≥60 Gy significantly improved OS and RFS. These findings support individualized radiotherapy strategies based on nodal response.
Authors
- Lu Cao (ORCID: https://orcid.org/0000-0001-6644-0963)
- Rong Cai (ORCID: https://orcid.org/0000-0001-6793-5765)
- Jiayi Chen (ORCID: https://orcid.org/0000-0001-6417-290X)
- Shuyan Li (ORCID: https://orcid.org/0000-0001-7028-4166)
- Zhe Xu (ORCID: https://orcid.org/0000-0001-5157-570X)
- Wei-Xiang Qi
- Gang Cai (ORCID: https://orcid.org/0000-0003-3323-1932)
- Dan Ou (ORCID: https://orcid.org/0000-0001-6427-4199)
- Cheng Xu (ORCID: https://orcid.org/0000-0003-1659-6198)
Institutions
- Ruijin Hospital (CN)
Publication Details
- Journal
- The Breast
- Published
- 2025-12-03
- DOI
- https://doi.org/10.1016/j.breast.2025.104670
- Primary Topic
- Breast Cancer Treatment Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00