Integration of gut microbiome and lipid metabolism reveals the anti-cancer effects of pentadecanoic acid on bladder cancer
Collectively, our findings demonstrate that PEA mitigates BC by reshaping the gut microbiome and modulating lipid metabolism, providing new insights into its molecular and therapeutic potential.
Authors
- Yingzhou Shen
- Anke Wesselius (ORCID: https://orcid.org/0000-0003-4474-9665)
- Richard T. Bryan (ORCID: https://orcid.org/0000-0003-2853-4293)
- Guiju Sun (ORCID: https://orcid.org/0000-0001-5969-2185)
- Kar Keung Cheng (ORCID: https://orcid.org/0000-0002-1516-1857)
- Nicholas David James (ORCID: https://orcid.org/0000-0002-7314-8204)
- Shaokang Wang (ORCID: https://orcid.org/0000-0002-7503-7655)
- Maurice Petrus Zeegers (ORCID: https://orcid.org/0000-0002-2387-083X)
- Lianmin Chen (ORCID: https://orcid.org/0000-0003-0660-3518)
- Jing Sui (ORCID: https://orcid.org/0000-0001-8223-9872)
- Hui Xia (ORCID: https://orcid.org/0000-0002-3603-1920)
- Wenchao Li (ORCID: https://orcid.org/0000-0002-3078-1421)
- Xiangdong Wang (ORCID: https://orcid.org/0009-0006-2958-5315)
- Yang Yu (ORCID: https://orcid.org/0000-0002-9138-9351)
- Ya‐Ting Chen (ORCID: https://orcid.org/0009-0001-3189-7426)
- Qirong Qin
- Evan Yi-Wen Yu (ORCID: https://orcid.org/0000-0001-7825-5087)
- Hao Zhang (ORCID: https://orcid.org/0009-0006-9483-834X)
- Shujin Wang (ORCID: https://orcid.org/0000-0002-5414-8276)
Institutions
- Tufts University (US)
- Institute of Cancer Research (GB)
- Anhui Medical University (CN)
- Nanjing University of Information Science and Technology (CN)
- Maastricht University (NL)
- Zhongda Hospital Southeast University (CN)
- Jean Mayer Human Nutrition Research Center on Aging (US)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Changzhou No.2 People's Hospital (CN)
- Anshan Hospital (CN)
- Southeast University (CN)
- University of Birmingham (GB)
- Nanjing Medical University (CN)
- Chongqing Medical University (CN)
- Nanjing University (CN)
Publication Details
- Journal
- BMC Medicine
- Published
- 2025-12-03
- DOI
- https://doi.org/10.1186/s12916-025-04554-5
- Citations
- 1
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.81