Delta Neutrophil Index as a Predictive Biomarker for Chorioamnionitis in Pregnancies Complicated by PPROM

Objective: Chorioamnionitis is an intra-amniotic infection involving the fetal membranes, amniotic fluid, or placenta, and is associated with adverse perinatal outcomes, particularly in pregnancies complicated by preterm premature rupture of membranes (PPROM).After membrane rupture; the risk of infection increases early diagnosis is essential to reduce the risks of neonatal sepsis, preterm birth, and maternal morbidity.Conventional diagnostic approaches are limited due to reliance on clinical signs and non-specific biomarkers.The delta neutrophil index (DNI), which reflects circulating immature granulocytes, has emerged as a rapid inflammatory marker.This study aimed to assess the diagnostic performance of DNI in predicting clinical chorioamnionitis in PPROM.Method: Three hundred singleton pregnancies with PPROM diagnosed between 24+0 and 33+6 weeks were retrospectively analyzed at a tertiary perinatology center between May 2020 and July 2023.Patients were classified according to the presence of clinical chorioamnionitis using the American College of Obstetricians and Gynecologists criteria.Maternal blood samples were obtained within one hour of admission and before administration of antenatal corticosteroids.DNI values were automatically calculated as the proportion of circulating immature granulocytes.Ama: Koryoamniyonit, fetal membranlar, amniyotik svy veya plasentay ieren intra-amniyotik bir enfeksiyon olup, zellikle preterm erken membran rptr (PPROM) ile komplike gebeliklerde olumsuz perinatal sonularn nemli bir nedenidir.Membran rptr sonras enfeksiyon riski artar ve erken tan yenidoan sepsisi, preterm doum ve maternal morbiditenin nlenmesinde kritik neme sahiptir.Rutin tan yntemlerinin doruluu klinik bulgulara ve zgl olmayan belirtelere dayanmas nedeniyle snrldr.Dolamdaki immatr granlosit dzeyini yanstan delta ntrofil indeksi (DNI), enfeksiyon iin hzl bir biyobelirte olarak ne kmaktadr.Bu alma, PPROM olgularnda klinik koryoamniyoniti ngrmede DNI'nn tansal performansn deerlendirmeyi amalamaktadr.