Treatment effectiveness and preference in patients with schizophrenia switched from oral standard of care atypical antipsychotics to aripiprazole once-monthly: a brief report over a six-month period
Transitioning to AOM from oral antipsychotics in schizophrenia patients was associated with significant improvements in clinical outcomes, symptom severity, and treatment satisfaction, with a favorable safety and tolerability profile. These findings support the use of AOM in early-stage schizophrenia and highlight its potential to enhance long-term adherence and functional recovery. Further long-term studies are warranted to assess the durability of these benefits and their impact on relapse prevention and quality of life.
Authors
- Giovanni Martinotti
- Mauro Pettorruso (ORCID: https://orcid.org/0000-0002-4164-3040)
- Giulia Giovannetti (ORCID: https://orcid.org/0000-0003-4830-0777)
- Andrea Miuli (ORCID: https://orcid.org/0000-0003-2431-0460)
- Gianluca Mancusi (ORCID: https://orcid.org/0000-0003-0866-0065)
- Daniele Di Battista
- Teresa Di Crosta
- Ornella Di Marco
- Marco Alessandrini (ORCID: https://orcid.org/0000-0002-2821-4620)
Institutions
- University of Chieti-Pescara (IT)
- ASL Roma (IT)
- Azienda Sanitaria Locale Roma 3 (IT)
Publication Details
- Journal
- Frontiers in Psychiatry
- Published
- 2025-12-03
- DOI
- https://doi.org/10.3389/fpsyt.2025.1680394
- Primary Topic
- Schizophrenia research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Otsuka Pharmaceutical
- H. Lundbeck A/S