Multi-omics integrated analysis identifies causal risk factors and therapeutic targets for diabetic retinopathy
This study systematically elucidates the key risk factors, potential molecular mechanisms, and core regulatory targets of DR through multi-omics integration, causal inference, and bioinformatics approaches. The results indicate that inflammation, immune dysregulation, and metabolic disorders play crucial roles in the pathogenesis of DR. Key genes such as LY9, ARHGAP1, and WWP2 could serve as potential intervention targets, offering theoretical foundations and strategic support for early warning and precision treatment of DR.
Authors
- Yige Zhang (ORCID: https://orcid.org/0000-0001-7331-1246)
- Zhaohui Gu (ORCID: https://orcid.org/0000-0003-1581-1327)
- Xiaofeng Hao (ORCID: https://orcid.org/0000-0001-6315-390X)
- Xi Chen (ORCID: https://orcid.org/0000-0001-5398-3854)
- Shuntai Chen (ORCID: https://orcid.org/0000-0002-6927-7492)
- Jing Xu (ORCID: https://orcid.org/0000-0002-8926-0890)
- Like Xie (ORCID: https://orcid.org/0000-0002-7746-3842)
- Mei Sun
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Beijing Shijingshan Hospital (CN)
- China Academy of Chinese Medical Sciences (CN)
- Guang’anmen Hospital (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-12-03
- DOI
- https://doi.org/10.1186/s12967-025-07353-x
- Primary Topic
- Retinal Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- China Academy of Chinese Medical Sciences