Total synthesis of maltepolide F
Herein, we present the total synthesis of the polyketide macrolide maltepolide F. D-Mannitol serves as the chiral pool material for constructing the tetrahydrofuran unit. Key steps in the synthesis include cyclo-etherification, Brown asymmetric allylation, the Evans aldol reaction, Yamaguchi esterification, and intramolecular Heck cyclization.
Authors
- Bashweshawar S. Dhulshette
- subhash ghosh (ORCID: https://orcid.org/0000-0002-5877-8910)
Institutions
- Indian Institute of Chemical Technology (IN)
- Academy of Scientific and Innovative Research (IN)
Publication Details
- Journal
- Organic & Biomolecular Chemistry
- Published
- 2025-12-03
- DOI
- https://doi.org/10.1039/d5ob01725d
- Primary Topic
- Synthetic Organic Chemistry Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00