Nucleopalladation strategy towards regioselective <i>N</i> -alkylation of indoles with unactivated olefins
A regioselective intermolecular nucleopalladation of indolines with unactivated olefins followed by oxidation is developed to access valuable <i>N</i>-alkyl indoles in high yields. This one-pot protocol features operational simplicity, scalability, and offers a strategic means to circumvent the intrinsic carbon-centered reactivity of indoles. Additionally, downstream product diversification was demonstrated through the functionalization of C(sp<sup>2</sup>)-H and C(sp<sup>3</sup>)-H bonds.
Authors
- Shib Nath Saha (ORCID: https://orcid.org/0009-0007-6913-5375)
- Neelima Gupta (ORCID: https://orcid.org/0000-0001-8909-3765)
- Mahiuddin Baidya (ORCID: https://orcid.org/0000-0001-9415-7137)
- Niloy Ballav
Institutions
- Indian Institute of Technology Madras (IN)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-12-03
- DOI
- https://doi.org/10.1039/d5cc06505d
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00