Impact of chronic social stress on molecular markers of skin regeneration during experimental excisional wounding
The findings demonstrate that chronic social stress impairs skin wound healing by disrupting the balance of apoptosis, cytoprotection, and proliferation at the molecular level. Suppression of pro-inflammatory and regenerative pathways, combined with enhanced oxidative stress and apoptosis, underlies the observed delays in tissue repair. These results highlight the importance of addressing psycho-social factors in the management of wound healing and suggest potential molecular targets for therapeutic intervention in stress-impaired tissue regeneration.
Authors
- Oleksandr Frolov (ORCID: https://orcid.org/0009-0001-5094-2501)
- Lyudmyla Makyeyeva (ORCID: https://orcid.org/0000-0002-3188-2638)
- Oleksandr Kamyshnyi (ORCID: https://orcid.org/0000-0003-3141-4436)
- Pavlo Petakh (ORCID: https://orcid.org/0000-0002-0860-4445)
- E. Aliyeva (ORCID: https://orcid.org/0000-0003-1287-674X)
- Igor F. Belenichev (ORCID: https://orcid.org/0000-0003-1273-5314)
Institutions
- National University Zaporizhzhia Polytechnic (UA)
- Zaporizhzhia State Medical and Pharmaceutical University (UA)
- I.Horbachevsky Ternopil National Medical University (UA)
- Uzhhorod National University (UA)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-12-03
- DOI
- https://doi.org/10.3389/fimmu.2025.1656214
- Primary Topic
- Wound Healing and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00