Multidimensional structural-functional coupling uncovers network dysregulation and predicts binge-eating severity in bulimia nervosa
In BN, macroscale white-matter organization is preserved, yet focal prefrontal functional decentralization and widespread, parcellation-robust SC-FC coupling changes invisible to single-modality analyses were observed. Multidimensional SC-FC coupling provides a sensitive neurobiological marker that explains clinically relevant variance in binge-eating behavior, highlighting its potential as a target for personalized diagnosis and intervention in BN.
Authors
- Yiling Wang (ORCID: https://orcid.org/0009-0001-5146-7829)
- Jing Yang (ORCID: https://orcid.org/0009-0000-1663-6781)
- Peng Zhang (ORCID: https://orcid.org/0000-0003-4278-0036)
- Weihua Li (ORCID: https://orcid.org/0009-0006-2163-3335)
- Miao Wang (ORCID: https://orcid.org/0000-0001-7099-6809)
- Lirong Tang
- Jiani Wang (ORCID: https://orcid.org/0000-0002-0869-3468)
- Zhenghan Yang (ORCID: https://orcid.org/0000-0002-8473-3257)
- Zhanjiang Li
- Xiaodan Ren
- Guowei Wu (ORCID: https://orcid.org/0000-0001-5121-8665)
- Zhenchang Wang (ORCID: https://orcid.org/0000-0002-9551-2660)
- Fengxia Yu
- Demin Kong
Institutions
- Peking University (CN)
- Beijing Anding Hospital (CN)
- Beijing Friendship Hospital (CN)
- Central Hospital of Zibo (CN)
- Institute of Mechanics (CN)
- Center for Life Sciences (CN)
Publication Details
- Journal
- BMC Medicine
- Published
- 2025-12-03
- DOI
- https://doi.org/10.1186/s12916-025-04556-3
- Primary Topic
- Eating Disorders and Behaviors
- Type
- article
- Field-Weighted Citation Impact
- 0.00