Inhibition of pro-apoptotic UPR pathways PERK/CHOP and IRE1/JNK protects differentiated SH-SY5Y cells against rotenone-induced toxicity
Targeting PERK- and IRE1-dependent pathways contributes to neuroprotection in ROT-based PD model, which indicates the potential of UPR inhibitors as therapeutic agents for PD.
Authors
- Wioletta Rozpędek‐Kamińska (ORCID: https://orcid.org/0000-0001-9206-1203)
- Michał Golberg (ORCID: https://orcid.org/0000-0003-4901-6444)
- Ireneusz Majsterek (ORCID: https://orcid.org/0000-0001-6231-3334)
- Grzegorz Galita (ORCID: https://orcid.org/0000-0002-1559-2796)
- Natalia Siwecka (ORCID: https://orcid.org/0000-0002-0308-580X)
- Wojciech Wiese (ORCID: https://orcid.org/0000-0002-0796-9717)
Institutions
- Medical University of Warsaw (PL)
- Medical University of Lodz (PL)
Publication Details
- Journal
- Frontiers in Molecular Neuroscience
- Published
- 2025-12-03
- DOI
- https://doi.org/10.3389/fnmol.2025.1700897
- Primary Topic
- Endoplasmic Reticulum Stress and Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Uniwersytet Łódzki