TNF-α exacerbates calcium influx via voltage-gated calcium channels in breast cancer cells: a nanoscale multimodal AFM study
These findings elucidate the mechanisms by which TNF-α modulates VGCC distribution and electrophysiological properties to amplify calcium signaling, ultimately triggering apoptosis. This study provides unprecedented insights into TNF-α-induced calcium dysregulation in cancer cells at the single-molecule level, offering a novel approach for investigating apoptosis and advancing targeted therapies for breast cancer and other malignancies.
Authors
- Rongrong Feng
- Junmei Chen (ORCID: https://orcid.org/0000-0001-6702-2763)
- Wei‐Dong Zhao (ORCID: https://orcid.org/0000-0003-0029-4400)
- Qianhui Xu (ORCID: https://orcid.org/0000-0002-9789-1107)
- Zhongwei Wang (ORCID: https://orcid.org/0000-0002-1476-5093)
- Haijian Zhong (ORCID: https://orcid.org/0000-0002-5396-559X)
- Jinsong Wei (ORCID: https://orcid.org/0000-0002-2822-356X)
- Huaiwei Zhang
Institutions
- Guangdong Medical College (CN)
- Gannan Medical University (CN)
- Affiliated Hospital of Guangdong Medical College Hospital (CN)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2025-12-03
- DOI
- https://doi.org/10.3389/fcell.2025.1633976
- Primary Topic
- Ion Channels and Receptors
- Type
- article
- Field-Weighted Citation Impact
- 0.00