Evaluation of a Bayesian dosing calculator for vancomycin in pediatric patients with augmented renal clearance
NextDose overestimated vancomycin concentrations in <i>a priori</i> predictions, suggesting it may not be suitable for initial dose calculations. Incorporating one or two measured concentrations significantly improved predictive accuracy, particularly in patients with ARC, supporting its use alongside therapeutic drug monitoring to personalize vancomycin monitoring.
Authors
- Muneera Al‐Jelaify
- Saeed Alqahtani (ORCID: https://orcid.org/0000-0002-3839-8187)
- Mashal M. Almutairi (ORCID: https://orcid.org/0000-0001-9746-4765)
- Abdullah Alsultan (ORCID: https://orcid.org/0000-0002-7013-8369)
- Noura M. Alajmi
- Ali M. Somily (ORCID: https://orcid.org/0000-0002-9634-6107)
- Manal Abouelkheir (ORCID: https://orcid.org/0000-0001-6331-4443)
- Huda Alshahrani
- Ghadeer Lafi Alfuhaydi
Institutions
- Qassim University (SA)
- King Saud Medical City (SA)
- King Saud University (SA)
- King Abdulaziz Medical City (SA)
- Misr International University (EG)
- King Khalid University (SA)
Publication Details
- Journal
- Frontiers in Pediatrics
- Published
- 2025-12-03
- DOI
- https://doi.org/10.3389/fped.2025.1683683
- Primary Topic
- Antimicrobial Resistance in Staphylococcus
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- King Abdulaziz City for Science and Technology