Gut microbiota-driven dysbiosis of the SCFA-immune axis in pediatric allergic rhinitis-constipation comorbidity: mechanisms and synbiotic remodeling
Gut dysbiosis in AR-FC comorbidity is associated with disruption of the microbiota-SCFA-immune axis, which may correlate with mucosal barrier defects and a potential bias toward T helper 2 (Th2) polarization. Although synbiotic therapy induced taxonomic shifts and improved gastrointestinal function, our findings highlight the need for strain-specific formulations to achieve comprehensive immune and intestinal restoration.
Authors
- Congfu Huang
- Bin Wu (ORCID: https://orcid.org/0000-0002-1882-3932)
- Hongbin Lin (ORCID: https://orcid.org/0000-0002-4057-7360)
- Wanli Yang (ORCID: https://orcid.org/0000-0003-0666-8063)
- Bing Ni (ORCID: https://orcid.org/0000-0002-4297-5346)
- Xiaojiao Zhang (ORCID: https://orcid.org/0000-0002-1909-7725)
Institutions
- Shenzhen Maternity and Child Healthcare Hospital (CN)
- Chinese University of Hong Kong, Shenzhen (CN)
- Weihai Maternal and Child Health Hospital (CN)
- Shenzhen Second People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-12-03
- DOI
- https://doi.org/10.3389/fimmu.2025.1639359
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00