Anatomically refined entorhinal cortex segmentation improves MRI-based early diagnosis of Alzheimer’s disease
These findings demonstrate that anatomically precise and expert-informed EC delineation improves the sensitivity of MRI-based biomarkers for early AD diagnosis. The proposed framework offers a practical and reproducible approach for studying subtle cortical changes that precede overt clinical symptoms.
Authors
- Hyun Kook Lim (ORCID: https://orcid.org/0000-0001-8742-3409)
- Seol‐Hee Baek (ORCID: https://orcid.org/0000-0002-3656-1833)
- Anna Jung
- Byung‐Jo Kim (ORCID: https://orcid.org/0000-0002-0445-7185)
- Sangyoon Park (ORCID: https://orcid.org/0000-0001-8779-6694)
- Jeong‐Won Lee (ORCID: https://orcid.org/0000-0002-6110-4909)
- Jong Hyun Kim (ORCID: https://orcid.org/0000-0002-3821-6873)
- Mincheol Yoon (ORCID: https://orcid.org/0009-0003-0697-915X)
- Yongha Gi
Institutions
- Korea University (KR)
- Korea Engineering Consultants Corporation (KR)
Publication Details
- Journal
- Frontiers in Aging Neuroscience
- Published
- 2025-12-03
- DOI
- https://doi.org/10.3389/fnagi.2025.1682106
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Korea Medical Device Development Fund
- National Research Foundation
- Ministry of Trade, Industry and Energy
- Ministry of Food and Drug Safety
- National Research Foundation of Korea
- Ministry of Science and ICT, South Korea