Eriodictyol alleviates ovarian dysfunction in a mouse model of premature ovarian failure via the PI3K/Akt/NF-κB pathway and suppression of macrophage inflammation
Eriodictyol alleviates chemotherapy-induced ovarian dysfunction by inhibiting the PI3K/Akt/NF-κB inflammatory pathway and suppressing macrophage-mediated damage to granulosa cells. These findings identify eriodictyol as a promising therapeutic candidate for POF.
Authors
- Min Sun (ORCID: https://orcid.org/0000-0002-8528-0050)
- Lusheng Liu
- Fangyu Sui
- Xinyu Wu
- Suxia Luo (ORCID: https://orcid.org/0000-0001-6805-7650)
- Miao Zhang (ORCID: https://orcid.org/0000-0003-4814-6159)
- Jianwei Wang (ORCID: https://orcid.org/0000-0002-0815-9476)
- Mingyao Qu
Institutions
- Heilongjiang University of Chinese Medicine (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
- Shanghai Traditional Chinese Medicine Hospital (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-12-03
- DOI
- https://doi.org/10.3389/fphar.2025.1710805
- Citations
- 1
- Primary Topic
- Reproductive Biology and Fertility
- Type
- article
- Field-Weighted Citation Impact
- 1.88