Common genetic polymorphisms define one-carbon metabolite responses to different forms of choline in healthy adult males
Unique metabolite signatures in one-carbon metabolism arise in response to supplemental intake of different forms of choline, driven by genetic variations that regulate choline homeostasis. Our findings highlight the importance of nutrient-gene interactions in deciphering the complexity of individual metabolic responses, supporting the emerging concept of precision nutrition.
Authors
- Marica Bakovic (ORCID: https://orcid.org/0000-0001-9081-3539)
- Justine Keathley (ORCID: https://orcid.org/0000-0002-9176-9645)
- Clara E. Cho (ORCID: https://orcid.org/0000-0002-9733-2516)
- Neil J. Butt
- Gia V. Shelp
- Elizabeth M. Poole (ORCID: https://orcid.org/0000-0002-4680-4587)
- Jianzhang Dong
Institutions
- University of Guelph (CA)
Publication Details
- Journal
- Frontiers in Nutrition
- Published
- 2025-12-03
- DOI
- https://doi.org/10.3389/fnut.2025.1620538
- Primary Topic
- Folate and B Vitamins Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Utah Agricultural Experiment Station
- Balchem
- Canadian Institutes of Health Research
- Natural Sciences and Engineering Research Council of Canada