Emergence of carbapenem-resistant Salmonella Typhi harboring blaNDM-5 in India: genomic evidence from a multicenter study
This is the first documented outbreak of <i>bla</i> <sub>NDM</sub>-mediated carbapenem-resistant <i>S</i>. Typhi, highlighting a new stage in the evolution of drug-resistant typhoid. The acquisition of high-risk plasmids by <i>S</i>. Typhi and their integration into successful epidemic lineages underscores the urgent need for strengthened genomic surveillance and inter-species AMR tracking. Our findings have direct implications for treatment guidelines, TCV implementation strategies, and efforts to prevent global dissemination of carbapenem-resistant <i>S</i>. Typhi.
Authors
- Camilla Rodrigues (ORCID: https://orcid.org/0000-0002-6105-6660)
- Jobin John Jacob (ORCID: https://orcid.org/0009-0009-7745-192X)
- Sukanya Verma
- Ashalatha S. Nair (ORCID: https://orcid.org/0000-0001-6369-9160)
- Kogaluru Shivakumar Santhosh
- S Mahantesh
- Priyadarshini A. Padaki (ORCID: https://orcid.org/0000-0003-0158-7619)
- R. T. Gaikwad
- Monisha Priya Teekaraman
- Kamini Walia (ORCID: https://orcid.org/0000-0002-1494-6919)
- Jacob John (ORCID: https://orcid.org/0000-0003-3654-5099)
- Tharani Priya Thirumoorthy (ORCID: https://orcid.org/0009-0005-9162-076X)
- Vasant Nagvekar
- Balaji Veeraraghavan (ORCID: https://orcid.org/0000-0002-8662-4257)
- Aravind Velmurugan
- J Sudarsana
- Jayanthi Savio
- Divya Joshi (ORCID: https://orcid.org/0000-0003-3190-8866)
- Pavithra Sathya Narayanan
- Savitha Nagaraj (ORCID: https://orcid.org/0000-0003-4996-4874)
- S Manasa
- Bhavana Jagannatha
Institutions
- University of Mumbai (IN)
- Christian Medical College, Vellore (IN)
- Lilavati Hospital & Research Centre (IN)
- P. D. Hinduja Hospital and Medical Research Centre (IN)
- Tamil Nadu Dr. M.G.R. Medical University (IN)
- Indian Council of Medical Research (IN)
- Kerala Institute of Medical Sciences (IN)
- St.John's Medical College Hospital (IN)
- Baby Memorial Hospital (IN)
- Fortis Hospital (IN)
- Indira Gandhi Institute of Child Health (IN)
- Sahyadri Hospital (IN)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-12-03
- DOI
- https://doi.org/10.3389/fmicb.2025.1685068
- Primary Topic
- Salmonella and Campylobacter epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Bill and Melinda Gates Foundation
- Christian Medical College, Vellore