Essential amino acids preserve intestinal barrier integrity via mitochondrial protection in obesity and gut inflammation
EAAs protect gut barrier integrity by sustaining mitochondrial biogenesis and function in IECs, thereby reducing obesity- and stress-induced inflammation. These findings highlight EAAs as a promising nutritional strategy to counteract mitochondrial dysfunction and prevent or reverse gut barrier disruption in obesity-related and inflammatory disorders.
Authors
- Agnese Segala (ORCID: https://orcid.org/0000-0002-9744-4681)
- Enzo Nisoli (ORCID: https://orcid.org/0000-0002-6670-1630)
- Ginetta Collo (ORCID: https://orcid.org/0000-0003-1888-5049)
- Michele O. Carruba (ORCID: https://orcid.org/0000-0003-4589-387X)
- Roberto Aquilani
- Maurizio Ragni (ORCID: https://orcid.org/0000-0001-6548-741X)
- Alessandra Valerio (ORCID: https://orcid.org/0000-0001-5844-2256)
- Luca Canciani
- Chiara Ruocco (ORCID: https://orcid.org/0000-0002-6544-2067)
- Letizia Spataro
- Alice Vetturi
- Giulia Sofia Marcotto
Institutions
- University of Milan (IT)
- University of Pavia (IT)
- University of Brescia (IT)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-12-03
- DOI
- https://doi.org/10.3389/fphar.2025.1694723
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Università degli Studi di Brescia