Restoration of peripheral ILC3s by washed microbiota transplantation improves lipid profiles in hyperlipidemia patients
Hyperlipidemia is associated with depletion of circulating ILC3s and reduced IL-22. Restoration of ILC3 subsets and enhancement of integrin α4-dependent hepatic homing are achieved after WMT, accompanying improvements in lipid metabolism.
Authors
- Xing‐Xiang He (ORCID: https://orcid.org/0000-0003-0007-8513)
- Wei Yue (ORCID: https://orcid.org/0000-0003-1668-7364)
- Jiayin Song (ORCID: https://orcid.org/0009-0003-7741-5685)
- Hao Wang (ORCID: https://orcid.org/0000-0002-0900-5807)
- Haojie Zhong (ORCID: https://orcid.org/0000-0001-6586-756X)
- Yishu Wang (ORCID: https://orcid.org/0000-0001-7537-1656)
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Guangdong Pharmaceutical University (CN)
- First Affiliated Hospital of Guangdong Pharmaceutical University (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-12-03
- DOI
- https://doi.org/10.3389/fimmu.2025.1688070
- Primary Topic
- IL-33, ST2, and ILC Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Basic and Applied Basic Research Foundation of Guangdong Province