Extracellular vesicles derived from pro-inflammatory M1 macrophages induce an inflammatory and invasive phenotype in melanoma cells
Our findings suggest that M1 EVs promote tumor-associated inflammation in melanoma cells through NF-ĸB signaling. This underscores the pivotal role of EV-mediated macrophage-tumor cell communication in cancer progression.
Authors
- Einari A. Niskanen (ORCID: https://orcid.org/0000-0001-9471-7026)
- Aino Rönkä (ORCID: https://orcid.org/0000-0001-6007-3648)
- Kirsi Rilla (ORCID: https://orcid.org/0000-0002-7862-5727)
- Kirsi Kainulainen (ORCID: https://orcid.org/0000-0001-9295-6699)
- Kaisa Mäki-Mantila (ORCID: https://orcid.org/0009-0009-0511-0763)
- Wafa Wahbi (ORCID: https://orcid.org/0000-0001-9416-5196)
- Piia Takabe
- Niina Aaltonen (ORCID: https://orcid.org/0000-0002-3931-1434)
- Sanna Pasonen‐Seppänen (ORCID: https://orcid.org/0000-0002-7131-1338)
- Laia Puig Pardas
Institutions
- University of Helsinki (FI)
- University of Eastern Finland (FI)
- Kuopio University Hospital (FI)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2025-12-03
- DOI
- https://doi.org/10.1186/s12964-025-02571-8
- Citations
- 1
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.81