Gut microbiota preserves bone mass through modulating the hyodeoxycholic acid–TGR5 axis
This study identified the GM-HDCA-TGR5 axis is a key pathway that affects bone mass and targeted intervention of HDCA represents potential therapeutic option for osteoporosis.
Authors
- Tong Wu (ORCID: https://orcid.org/0000-0001-9968-9909)
- Wan-Qiong Yuan
- Jie Huang (ORCID: https://orcid.org/0000-0002-3212-4804)
- Chunli Song (ORCID: https://orcid.org/0000-0002-3690-9457)
- Yundi Zhang (ORCID: https://orcid.org/0009-0002-0291-9849)
- Chen Huang (ORCID: https://orcid.org/0000-0002-7092-7587)
- Hao Liu (ORCID: https://orcid.org/0000-0003-1474-3828)
- Jie He (ORCID: https://orcid.org/0009-0006-5954-0687)
- Huan Wang (ORCID: https://orcid.org/0000-0001-8419-8402)
- Xuan-Qi Zheng
Institutions
- Peking University (CN)
- Spinal Research (GB)
- Peking University Third Hospital (CN)
Publication Details
- Journal
- Gut Microbes
- Published
- 2025-12-02
- DOI
- https://doi.org/10.1080/19490976.2025.2593088
- Primary Topic
- Bone health and osteoporosis research
- Type
- article
- Field-Weighted Citation Impact
- 0.00