Dysbiosis‐Mediated Inflammation: A Pathophysiological Link Between Rheumatoid Arthritis and Periodontitis
We demonstrate a mutualistic influence of RA and PD, beginning with RA-induced dysbiosis of the periodontal microbiome, progressing to periodontal inflammation and culminating in PD-driven exacerbation of systemic inflammation.
Authors
- Shweta Saraswat (ORCID: https://orcid.org/0000-0001-6847-2774)
- Iain Chapple (ORCID: https://orcid.org/0000-0003-2697-7082)
- Stefan Serban (ORCID: https://orcid.org/0000-0001-7911-688X)
- Isabel Lopez‐Oliva (ORCID: https://orcid.org/0000-0003-0965-8768)
- Thomas Dietrich (ORCID: https://orcid.org/0000-0002-2557-7645)
- Akshay D. Paropkari (ORCID: https://orcid.org/0000-0003-2284-7061)
- Andrew D. Filer (ORCID: https://orcid.org/0000-0001-8164-6249)
- Melissa M. Grant (ORCID: https://orcid.org/0000-0003-1154-7266)
- Paola de Pablo (ORCID: https://orcid.org/0000-0003-2859-7147)
- Purnima Kumar (ORCID: https://orcid.org/0000-0001-5844-1341)
- Karim Raza (ORCID: https://orcid.org/0000-0003-1570-1232)
- Praveen Sharma (ORCID: https://orcid.org/0000-0001-6435-4842)
Institutions
- University of Leeds (GB)
- Queen Mary University of London (GB)
- University of Michigan (US)
- Sandwell & West Birmingham Hospitals NHS Trust (GB)
- The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (US)
- Birmingham Community Healthcare NHS Trust (GB)
- Arthritis UK (GB)
- Kiko Labs (United States) (US)
- NIHR Birmingham Biomedical Research Centre (GB)
- The Ohio State University (US)
- University of Birmingham (GB)
Publication Details
- Journal
- Journal Of Clinical Periodontology
- Published
- 2025-12-02
- DOI
- https://doi.org/10.1111/jcpe.70063
- Primary Topic
- Oral microbiology and periodontitis research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Government of the United Kingdom
- National Cancer Institute