Causal inference of CLEC5A and ISG20 in atherosclerosis: integrating Mendelian randomization and eQTL evidence
This study represents the first to elucidate the molecular mechanism by which ISG20 promotes AS progression through macrophage lipid accumulation and inflammatory responses, positioning it as a potential novel therapeutic target for AS.
Authors
- Lijuan Shao (ORCID: https://orcid.org/0000-0001-7980-2003)
- Yongchao Yu (ORCID: https://orcid.org/0000-0003-4235-0079)
- Xiangang Mo (ORCID: https://orcid.org/0000-0001-6354-7669)
- Ya Zhang (ORCID: https://orcid.org/0009-0008-3796-3771)
- Tianhui Wang (ORCID: https://orcid.org/0000-0003-2530-1101)
- Yuan Zhu (ORCID: https://orcid.org/0000-0001-9419-6291)
- Qian Tian
- Lan Wang
Institutions
- Guiyang Medical University (CN)
- Affiliated Hospital of Guizhou Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-12-03
- DOI
- https://doi.org/10.3389/fimmu.2025.1644135
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00