Lysozyme supplement enhances antioxidant capacity and regulates liver glucolipid metabolism in weaned piglets

The results indicate that dietary LZ supplementation enhances the hepatic antioxidant defense system, likely through activation of the Nrf2 signaling pathway. Concurrently, LZ modulates lipid metabolism by promoting fatty acid oxidation (via up-regulation of <i>PPARα</i> and <i>CPT1α</i>) and inhibiting lipogenesis (via down-regulation of <i>SREBP1</i> and <i>SCD</i>). The up-regulation of key gluconeogenic genes suggests improved hepatic glucose production. In conclusion, LZ improves antioxidant capacity and regulates glucolipid metabolism in the liver of weaned piglets, supporting its potential as a functional feed additive in pig production.