Distinct Pituitary-Adrenal Responses to Hypoglycemia in Type 1 and Type 2 Diabetes
Distinct diabetes subtypes demonstrate divergent pituitary-adrenal counter-regulatory responses to hypoglycemia, suggesting unique pathogenic mechanisms contributing to glycemic variability. The exaggerated GH response in T1DM may aggravate glucose fluctuations, whereas elevated ACTH and cortisol in T2DM could perpetuate insulin resistance.
Authors
- Bo Ding (ORCID: https://orcid.org/0000-0002-5577-7015)
- Xiaowei Zhu (ORCID: https://orcid.org/0000-0002-5731-3177)
- Rengna Yan (ORCID: https://orcid.org/0000-0002-1755-3045)
- Yun Hu (ORCID: https://orcid.org/0000-0002-4477-3641)
- Jianhua Ma (ORCID: https://orcid.org/0000-0001-9383-2559)
- Tingting Cai (ORCID: https://orcid.org/0009-0005-0879-0291)
Institutions
- Wuxi People's Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Endocrinology and Metabolism
- Published
- 2025-12-03
- DOI
- https://doi.org/10.3803/enm.2025.2479
- Primary Topic
- Growth Hormone and Insulin-like Growth Factors
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China