Delayed Effect After Procedural Sedation With Oral Ketamine and Midazolam
In 2025, we reported our experience with the following regimen for pediatric ED procedural sedation: 6 mg/kg oral (PO) ketamine (max 200 mg) and 0.5 mg/kg PO midazolam (max 15 mg). We present 2 children who received this regimen with respiratory depression after apparent recovery. PO ketamine and midazolam may cause a delayed sedative effect, which may limit its usefulness.
Authors
- Jeannine Del Pizzo
- Lisa M. McAndrew (ORCID: https://orcid.org/0000-0002-1350-8773)
Institutions
- Children's Hospital of Philadelphia (US)
- Community Health Systems - Dupont Hospital (US)
- Nemours Children's Health System (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Pediatric Emergency Care
- Published
- 2025-12-03
- DOI
- https://doi.org/10.1097/pec.0000000000003518
- Primary Topic
- Anesthesia and Sedative Agents
- Type
- article
- Field-Weighted Citation Impact
- 0.00